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Sterols and stanols are available in supplements and are also added to foods such as some margarines, orange juice, or yogurt. These can lower LDL, the “bad” cholesterol, by up to 15%. Cholesterol experts recommend 2 grams per day. Heber D, Yip I, Ashley JM, et al. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Adverse events were not observed in animal reproduction studies. There are reports of congenital anomalies following maternal use of HMG-CoA reductase inhibitors in pregnancy; however, maternal disease, differences in specific agents used, and the low rates of exposure limit the interpretation of the available data Godfrey, 2012; Lecarpentier, 2012. Cholesterol biosynthesis may be important in fetal development; serum cholesterol and triglycerides increase normally during pregnancy. The discontinuation of lipid lowering medications temporarily during pregnancy is not expected to have significant impact on the long term outcomes of primary hypercholesterolemia treatment.

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There, it is eliminated from the body. How Do Statin Drugs Work? Wang AH, Zhang GD. Comparison of the therapeutic effects of Xuezhikang and Lescol for treatment of hyperlipidemia. Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. Drinking alcohol might harm the liver. Red yeast might also harm the liver. Taking red yeast along with alcohol might increase the risk of liver damage. Do not drink alcohol if you are taking red yeast.

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Avoid drinking alcohol. It can raise triglyceride levels, and may also damage your liver while you are taking TriCor. LDL-C value was 124. If you become or think you may be pregnant, tell your doctor right away.


Dronedarone: May increase the serum concentration of Simvastatin. AUC0-24h for total ezetimibe. Retrieved 3 Nov 2015. Niacin: May enhance the myopathic rhabdomyolysis effect of Simvastatin. Niacin may increase the serum concentration of Simvastatin.

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What Are the Side Effects of Cholesterol-Lowering Drugs? In the UK, the patent for simvastatin had expired by 2004. Multicenter clinical trial of the serum lipid-lowering effects of a Monascus purpureus red yeast rice preparation from traditional Chinese medicine. The control group had no such change. Grapefruit juice should be avoided during simvastatin treatment. VYTORIN to cholestyramine may be reduced by this interaction. If you have any questions about simvastatin, please talk with your doctor, pharmacist, or other health care provider. Diabetes mellitus: Increases in HbA 1c and fasting blood glucose have been reported with HMG-CoA reductase inhibitors; however, the benefits of statin therapy far outweigh the risk of dysglycemia. Age and Gender. As we get older, cholesterol levels rise. Reduce the risk of non-fatal and stroke. Cholesterol-lowering drugs are most effective when combined with a low-cholesterol diet and exercise program. Li DX, Li YF Lu HY. Comparison of the effects of Xuezhikang with inositol hexanicotinate on lipid profile modification. The spinal cord runs through an opening in the bones called the spinal canal. occurs when that opening narrows. In some cases, bone, ligament, and disc tissue grows into the spinal canal and presses on the nerves that branch out from the spinal cord. The tissue can also squeeze and irritate or injure the spinal cord itself. In most cases, spinal stenosis occurs in the lower back and neck. It can occur in your upper or middle back, but this is rare. Retrieved 22 April 2014. Mean plasma level of HMG-CoA reductase inhibitory activity is increased approximately 45%. Azithromycin Systemic: May enhance the myopathic rhabdomyolysis effect of Simvastatin.

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Gemfibrozil Lopid can affect the muscles. Red yeast can also affect the muscles. Taking gemfibrozil along with red yeast might increase the risk of muscle problems. European Society of Cardiology: “Statins Prevent Cataracts. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. Clinical observations on Diao Zhibituo for treatment of hyperlipidemia. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. So does taking a statin mean you can sit on the couch and eat bacon all day? The Johns Hopkins Lupus Center: “Cholesterol Medications Statins. This is not really a disease but a term used to describe the normal changes that occur in your spinal discs as you age. Over time, the discs in your spine break down, or degenerate. A loss of fluid in the discs or tiny tears or cracks in the outer layer of the discs can occur over time. Asunaprevir: May increase the serum concentration of HMG-CoA Reductase Inhibitors. Do NOT take more than the recommended dose without checking with your doctor. Lu GP, Huo ShQ. Comparison of the effects of Xuezhikang with simvastatin on lipid profile modification in patients with hypercholesterolemia. Continue to use colchicine even if you feel well. Do not miss any doses. ditropan

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Bi JZ, Ma SZ Li YQ. Observations on the therapeutic effects of Diao Zhibituo for treatment of hyperlipidemia. Lai, M. M. Efficacy of Monascus purpureus Went rice on lowering lipid ratios in hypercholesterolemic patients. Zhang G, M XY C XB H X M JK W MH. Study of Xuezhikang and atorvastatin on mixed type hyperlipidemia. Concomitant intake of grapefruit juice and simvastatin should be avoided. Huang HN, Hua YY, Bao GR, Xie LH. The quantification of monacolin K in some red yeast rice from Fujian province and the comparison of the other product. C. Store away from heat, moisture, and light. Do not store in the bathroom. Zhonglin, H. Toxicity study for Monascus purpureus red yeast extract. Chen ZM. Comparison of the therapeutic effects of simvastatin and Zhibituo for treatment of hyperlipidemia. At first, 10 mg once a day in the evening. Your doctor may increase your dose as needed. However, the dose is usually not more than 40 mg per day. Use simvastatin with caution in the ELDERLY; they may be more sensitive to its effects, especially muscle problems. Diabetes Care, December 2004; vol 27: pp 2777-2783. CoQ10 supplements on your own, however. Work with your doctor when you take any supplement. Lilja JJ, Neuvonen M, Neuvonen PJ July 2004. lamisil

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They block a protein called PCSK9 to make it easier for the body to remove LDL from your blood. Surgical patients: The manufacturer recommends temporary discontinuation for elective major surgery, acute medical or surgical conditions, or in any patient experiencing an acute or serious condition predisposing to renal failure eg, sepsis, hypotension, trauma, uncontrolled seizures. Based on current research and clinical guidelines Fleisher, 2009 HMG-CoA reductase inhibitors should be continued in the perioperative period. Postoperative discontinuation of statin therapy is associated with an increased risk of cardiac morbidity and mortality. St John's Wort: May increase the metabolism of HMG-CoA Reductase Inhibitors. Management: Consider avoiding the concomitant administration of St Johns Wort with interacting HMG-CoA reductase inhibitors in order to avoid the potential for decreased antilipemic effects. Monitor for decreased effects during concomitant therapy. Pandey, A. Solid-state fermentation for the production of Monascus pigments from jackfruit seed. Bioresour. Yang, C. Clinical observation of the effects of xuezhikang on older primary hyperlipidemia patients. CYP3A4 Inhibitors Strong: May increase the serum concentration of Simvastatin. Studies show that statins lower the chance of a “cardiovascular event” such as a heart attack. Lansheng, G. Comparison of the effects of Xuezhikang and Simvastatin on lipid profile modification in patients with hypercholesterolemia. Lin, C. C. Red Yeast Rice for a patient with olanzapine-induced dyslipidemia: a test-and-retest case report. Prog. Many studies back up their benefits. For examp le, one small study compared a standard cholesterol-lowering diet with a diet that replaced one-fifth of the calories with pecans. Karl M, Rubenstein M, Rudnick C, Brejda J. A multicenter study of nutraceutical drinks for cholesterol evaluating effectiveness and tolerability. Ramsey, LB; Johnson, SG; Caudle, KE; Haidar, CE; Voora, D; Wilke, RA; Maxwell, WD; McLeod, HL; Krauss, RM; Roden, DM; Feng, Q; Cooper-DeHoff, RM; Gong, L; Klein, TE; Wadelius, M; Niemi, M October 2014. Who should not take VYTORIN?

Does simvastatin interact with other medications

Your body needs cholesterol for cell structure, nerve function, digestion and many other vital processes. Your body makes its own cholesterol in the liver. Fatty foods and meats also contain cholesterol, which ends up floating around in the bloodstream. Overtime, this extra cholesterol adheres to the walls of arteries, forming a rigid plaque that can restrict blood flow. Sometimes, this restriction is so drastic it can cause heart attacks and strokes, among other serious cardiovascular problems. This medication may rarely cause liver problems. Wigger-Alberti W, Bauer A, Hipler UC, Elsner P. Anaphylaxis due to Monascus purpureus-fermented rice red yeast rice. Pan, T. M. Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. Most people who take statin drugs tolerate them very well. But some people experience side effects. Take simvastatin by mouth with or without food, preferably in the evening, unless directed otherwise by your doctor. The dose of simvastatin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of simvastatin. trazodone

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China Coronary Secondary Prevention Study Group. China coronary secondary prevention study CCSPS. Lipid regulating therapy with xuezhikang for secondary prevention of coronary heart disease. The clinical observation of the medical treatment for hyperlipidemia with Xuezhikang. Used as a complement to traditional, Western medicine, massage can promote relaxation and reduce or side effects of treatment. Maintaining a healthy lifestyle while taking a statin can improve the effectiveness of the drug. Ethel Siris, MD: Let's talk about calcium and vitamin D. Everybody needs enough. If you're already getting enough from your diet, you don't take extra. It won't help. What if you're not getting enough? Ticagrelor: May increase the serum concentration of Simvastatin. Bargossi AM, Battino M, Gaddi A, et al. Exogenous CoQ10 preserves plasma ubiquinone levels in patients treated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Heber D, Lembertas A, Lu QY, et al. An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Quan SL, Wang W Qu XW Chen J. Controlled observation on therapeutic effects of Xuezhikang and simvastatin for treatment of hypercholesterolemia. When you take a statin, you do more than improve your cholesterol levels. I'm starting physical therapy on Friday May 11, 2012. It's only for my right Achilles tendon. Just saw an abstract on Mendeley. Statins may also help to stabilize plaques in the arteries. That makes heart attacks less likely. INR in patients who had ezetimibe added to warfarin. Chinese patients; some non-US labeling state this combination is not recommended in any Asian patients. online cardura

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Simvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Apo B -19% and -5%; and non-HDL-C -23% and -5%. Chen LL, Liu J. The lipid regulation function of Xuezhikang on hypercholesterolemia. Simvastatin acid refers to the β-hydroxyacid of simvastatin. Make sure any doctor or dentist who treats you knows that you are using simvastatin. You may need to stop using simvastatin if you have major surgery, a major injury, or you develop other serious health problems. If you have 2 or more risk factors for heart disease, you are at moderate risk, depending on what heart disease risk factors you have. Your doctor may recommend lifestyle changes, but most people require cholesterol-lowering drugs, along with an appropriate diet and exercise program. Simvastatin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Huang GZ, Yang S Wu ZG. Observation on therapuetic effect of Zhibituo for treatment of hyperlipidemia. See USP Controlled Room Temperature. Fu, H. and Zhang, B. Effect of xuezhikang on hyperlipidemia of chronic renal failure patients with peritoneal dialysis. Use with caution in patients who consume large amounts of ethanol or have a history of liver disease. Use is contraindicated with active liver disease and with unexplained transaminase elevations.

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Gao, R. L. Effects of xuezhikang, an extract of cholestin, on lipid profile and C-reactive protein: a short-term time course study in patients with stable angina. Clin Chim. Corio, R. Studi clinici su Normolip5, integratore alimentare per il controllo del colesterolo. Xie, S. and Duan, Z. Xuezhikang capsule regulates blood lipids with high efficacy: an overview of its preparation, pharmacology, toxicology, and results of clinical trials. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Some recommend that everyone over age 20 should get their measured at least once every 5 years. The test that is performed is a blood test called a lipoprotein profile. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have unusual tiredness or a fever. These could be symptoms of serious muscle problems, such as myopathy or immune-mediated necrotizing myopathy IMNM. Myopathy is more common when high doses of simvastatin eg, 80 milligrams are used, but some people get myopathy with lower doses. Fibrates lower triglyceride levels and can increase HDL and lower LDL. It's thought that fibrates enhance the breakdown of triglyceride-rich particles and decrease the secretion of certain blood fats. The main side effects are flushing, itching, tingling, and headache. Aspirin can reduce many of these symptoms. Speak with your doctor first, though, before taking aspirin. Research studies suggest that even though niacin may improve your cholesterol numbers, it does not appear to lower your risk of heart disease, especially if you are already taking a statin. buy glimepiride johannesburg

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Tell your doctor or dentist that you take simvastatin before you receive any medical or dental care, emergency care, or surgery. Simvastatin may need to be stopped for a few days before certain types of surgery. At first, 10 to 20 milligrams mg once a day in the evening. For high risk patients who may develop heart disease, your doctor may start your dose at 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day. Such patients merit closer monitoring. This condition, though uncommon, can take a long time to resolve. Wilke, RA; Ramsey, LB; Johnson, SG; Maxwell, WD; McLeod, HL; Voora, D; Krauss, RM; Roden, DM; Feng, Q; Cooper-Dehoff, RM; Gong, L; Klein, TE; Wadelius, M; Niemi, M; Clinical Pharmacogenomics Implementation Consortium, CPIC July 2012. Sept. 10, 2002; vol 106: pp 1327-1332. order hydrea online shopping uk

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How Is High Cholesterol Treated? Zocor had an original patent expiry date of January 2006, but was extended by the United States Patent Trademark Office PTO to expire on June 23, 2006. Hua D. Comparative Observation of simvastatin and Xuezhikang for patients with hyperlipidemia. Using simvastatin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. There was no effect on plasma levels. generic nizoral launch

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Zhiwei, S. A prospective study on Zhitai capsule in the treatment of primary hyperlipidemia. This information should not be used to decide whether or not to take simvastatin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about simvastatin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to simvastatin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using simvastatin.

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Wang J, Lu A, Chi J. Multicenter clinical trial of the serum lipid-lowering effects of a monascus purpureus red yeast rice preparation from traditional Chinese medicine. Telaprevir: May increase the serum concentration of Simvastatin. Cholestin inhibits cholesterol synthesis and secretion in hepatic cells HepG2. This is a webiste written by a former NASA astronaut doctor Dr. Graveline who experinced severe statin reactions himself and has studied the problem and collected info on the subject for many years. You can check out all your symptoms there and read accounts from others with statin reaction issues. He explains his recommendations for statin recovery as well. He has written several books on the subject and I have purchased and recommend them. tinidazole

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Yang WJ, Fu XJ. Comparison of the therapeutic effects of Zhibituo and simvastatin for treatment of hyperlipidemia. Caduet is a combination of a statin Lipitor and a blood pressure-lowering drug called Norvasc. Vytorin is a combination of a statin and a cholesterol absorption inhibitor simvastatin and ezetimibe. Do not keep outdated medicine or medicine no longer needed.

Conivaptan: May increase the serum concentration of CYP3A4 Substrates. Deng YM, Meng MK Liao YZ. Clinical observation of Xuezhikang on treatment of elderly patients with primary mixed hyperlipidemia. CVD or two or more other CVD risk factors are present in the adolescent patient. albendazole

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